Gems & Special runes
Some of the items might have empty slots for gems.

In order to apply gem on item, you have drag&drop gem on desired item.

Gems can be dropped by hostile mobs in any world or traded by some NPC. Also needs to be noted that, stats of dropped gems are based on mob levels, meaning, higher level mobs drop gems with better stats.
List of all gem types and their advantages.
Overworld gems - low tier gems, as max level in overworld is around 75 lvl.
Hell gems - midrange tier gems, can be found only in hell, as max level in hell is 130 level, it is very good.
Dungeon gems - some of the gems feature extra guarantied stat. For example Box Arena gems have extra 1 negative and 1 positive stat.
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